Protective Effects of Phytic Acid on CCl4-Induced Liver Fibrosis in Mice

Liver fibrosis is the main pathological feature of various chronic liver diseases that can progress to cirrhosis. However, no effective treatment strategy for available. Phytic acid (PA) a natural plant compound found in cereals, legumes, and rapeseed. Currently, there are few reports on its relationship with fibrosis. Herein, we explored effects PA In this study, model was constructed by intraperitoneal injection CCl4 intragastric administration sodium phytate (100 mg/kg) or silymarin five times week. The could significantly increase content alanine aminotransferase (ALT) aspartate (AST) serum induce damage cells, infiltration inflammatory factors, deposition collagen fibers tissue. Compared group, reduced AST ALT. Also, alleviated cell infiltration, area, hydroxyproline (Hyp) tissue, as well downregulated α-smooth muscle actin (α-SMA) I (Col-1). Mechanistically, PI3K, p-AKT, p-p65, p-IκBα tissue release cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6). conclusion, might ameliorate inhibiting NF-κB PI3K/AKT signaling pathways.